Potential effect

guidelines section 4.5	A	V	U
W   Potential effect
W1   Reactivity
W1.1   Cell-free or calculated reactivity Input uncertainty lowmediumhigh
W1.1   Redox activity W1.1   Redox activity low medium high not known	-	-	-
W1.1   Photocatalytic activity W1.1   Photocatalytic activity low medium high not known	-	-	-
W1.1   Biological oxidative damage (BOD) W1.1   Biological oxidative damage (BOD) low medium high not known	-	-	-
W1.2   Cellullar reactivity Input uncertainty lowmediumhigh
W1.2   Induction of mediators of inflammation (IL-8, IL-1β, TNFα) W1.2   Induction of mediators of inflammation (IL-8, IL-1β, TNFα) low medium high not known	-	-	-
W1.2   ROS induction W1.2   ROS induction low medium high not known	-	-	-
W1.2   GSH reduction W1.2   GSH reduction low medium high not known	-	-	-
W1.2   Protein carbonylation W1.2   Protein carbonylation low medium high not known	-	-	-
W2   Stability Input uncertainty lowmediumhigh
W2AV   Stability (half-life) of the primary particles present in the nanomaterial in the body W2AV   Stability (half-life) of the primary particles present in the nanomaterial in the body hours days-weeks months not known	-	-
W2U   Stability (half-life) of the primary particles present in the nanomaterial under environmental conditions W2U   Stability (half-life) of the primary particles present in the nanomaterial under environmental conditions hours days-weeks months not known			-

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